Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29
After publishing a genome scan and follow-up fine mapping, suggesting schizophreniaand bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (singlenucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage wasperformed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156)was observed with SNP rs225. In short, we found significant linkage scores most telomeric onchromosome 3q29, spanning 3.46 Mbp (7 SNPs).
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