Most coal mines are in the seismic intensity 7（12 degree evaluation or even higher in China. Large-scale mined-out spaces formed in the strata have been increased, because of excessive coal mining exploitation. The seismic response of mine surface will be different from other places because of the impact of the mined-out area on the seismic wave’s propagation. This paper studies the seismic response acceleration, peak acceleration and displacement at the ground surface above unstable and compacted mined-out areas by FLAC3D numerical models for various conditions. The results of the numerical simulation are consistent with the surface seismic response of Zhaogezhuang Mine in the Tangshan earthquake, 1976. It has been shown that the seismic damage to the surface above the mined-out area especially to the surface above the boundary of the mined-out area was slightly less than those in other places at the ground surface, and the seismic damage to the surface which is 2-3 times the size of mined-out area’s width, away from the mined-out area boundary was more severe than those in unexploited places. The surface area which is more than 4 times the size of the mined-out area’s width away from the mined-out area boundary was not affected by seismic damage.