Molecular Horizons - formerly the Centre for Medical and Molecular Bioscience (CMMB) - brings together a multidisciplinary team of chemists and biologists with a common interest in the molecular basis of disease and disease prevention from the School of Chemistry and School of Biological Sciences at the University of Wollongong.

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Papers from 2011

EX1 hydrogen-deuterium exchange in an all-helical protein and its cyclized derivative at neutral pH, Thitima Urathamakul, Neal K. Williams, Nicholas E. Dixon, and Jennifer L. Beck

Ethnobotanical authentication and identification of Khrog-sman (lower elevation medicinal plants) of Bhutan, Phurpa Wangchuk, Stephen G. Pyne, and Paul A. Keller

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An assessment of three Harpacticoid Copepod species for use in ecotoxicological testing, Daniel J. Ward, Victor Perez-Landa, David A. Spadaro, Stuart L. Simpson, and Dianne F. Jolley

Binding inhibitors of the bacterial sliding clamp by design, Gene Wijffels, Wynona M. Johnson, Aaron J. Oakley, Kathleen Turner, V. Chandana Epa, Susan J. Briscoe, Mitchell Polley, Andris J. Liepa, Albert Hofmann, Jens Buchardt, Caspar Christensen, Pavel Prosselkov, Brian P. Dalrymple, Paul F. Alewood, Philip A. Jennings, Nicholas E. Dixon, and David A. Winkler

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Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-beta production independent of cholesterol efflux activity, Kim S. Woojin, Andrew F. Hill, Michael L. Fitzgerald, Mason W. Freeman, Genevieve Evin, and Brett Garner

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Clusterin facilitates in vivo clearance of extracellular misfolded proteins, Amy R. Wyatt, Justin J. Yerbury, Paula Berghofer, I Greguric, Andrew Katsifis, Christopher Dobson, and Mark R. Wilson

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Synthesis of 3-halo-2,5-disubstituted furans via CuX mediated cyclization-halogenation reactions, Arife Yazici and Stephen G. Pyne

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Kinase inhibitory, haemolytic and cytotoxic activity of three deep-water sponges from North Western Australia and their fatty acid composition, Ana Zivanovic, Natalie J. Pastro, Jane Fromont, Murray Thomson, and Danielle Skropeta

Papers from 2010

Transport of metal ions across an electrically switchable cation exchange membrane based on polypyrrole doped with a sulfonated calix[6]arene, Marceline N. Akieh, Stephen F. Ralph, Johan Bobacka, and Ari Ivaska

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Spatial variability of cadmium, copper, manganese, nickel and zinc in the Port Curtis Estuary, Queensland, Australia, Brad M. Angel, Leigh T. Hales, Stuart L. Simpson, Simon C. Apte, Anthony A. Chariton, Damon A. Shearer, and Dianne F. Jolley

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Toxicity to Melita plumulosa from intermittent and continuous exposures to dissolved copper, Brad M. Angel, Stuart L. Simpson, and Dianne F. Jolley

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs, Vicki Athanasopoulos, Andrew Barker, Di Yu, Andy H-M. Tan, Monika Srivastava, Nelida Contreras, Jianbin Wang, Kong-Peng Lam, Simon H. J Brown, Christopher C. Goodnow, Nicholas E. Dixon, Peter J. Leedman, Robert Saint, and Carola G. Vinuesa

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Synthesis of hyacinthacine B-3 and purported hyacinthacine B-7, Christopher W.G. Au, Robert J. Nash, and Stephen G. Pyne

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Oat β-glucan supplementation does not enhance the effectiveness of an energy-restricted diet in overweight women, Eleanor J. Beck, Linda C. Tapsell, Marijka J. Batterham, Susan M. Tosh, and Xu-Feng Huang

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The quaternary organization and dynamics of the molecular chaperone HSP26 are thermally regulated, J. L. Benesch, Andrew Aquilina, Andrew Baldwin, Agata Rekas, Florian Stengel, Robyn Lindner, Eman Basha, G. Devlin, J. Horwitz, Elizabeth Vierling, John Carver, and C. V. Robinson

New diffusive gradients in a thin film technique for measuring inorganic arsenic and selenium (IV) using a titanium dioxide based adsorbent, William Bennett, Peter Teasdale, Jarad Panther, David Welsh, and Dianne F. Jolley

Advances in mass spectrometry for lipidomics, Stephen J. Blanksby and Todd Mitchell

ANS binding reveals common features of cytotoxic amyloid species, Benedetta Bolognesi, Janet R. Kumita, Teresa P. Barros, Elin K. Esbjorner, Leila M. Luheshi, Damian C. Crowther, Mark R. Wilson, Christopher M. Dobson, Giorgio Favrin, and Justin J. Yerbury

Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats, Antonio M. Bonin, Jaime A. Yanez, Chie Fukuda, Xiao Wei Teng, Carolyn T. Dillon, Trevor W. Hambley, Peter A. Lay, and Neal M. Davies

Binaphthyl-based dicationic peptoids with therapeutic potential, J. B. Bremner, Paul A. Keller, Stephen G. Pyne, Timothy Boyle, Zinka Brkic, Dorothy David, Adel Garas, Jody Morgan, Mark Robertson, Kittiya Somphol, Michael Miller, Adam Howe, Paul Ambrose, Sujata Bhavnani, Thomas Fritsche, Douglas Biedenbach, Ronald Jones, Robert Buckheit Jr., K. Watson, Dean Baylis, Jonathon A. Coates, John Deadman, Dharshini Jeevarajah, Andrea McCracken, and David I. Rhodes

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1, J. B. Bremner, Paul A. Keller, Stephen G. Pyne, Timothy Boyle, Zinka Brkic, Dorothy David, Mark Robertson, Kittiya Somphol, Dean Baylis, Jonathon Coates, John Deadman, Dharshini Jeevarajah, and David I. Rhodes

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2, J. B. Bremner, Paul A. Keller, Stephen G. Pyne, Timothy Boyle, Zinka Brkic, Jody Morgan, Kittiya Somphol, Jonathon Coates, John Deadman, and David I. Rhodes

Synthesis of berberine-efflux pump inhibitor hybrid antibacterials, J. B. Bremner and Michael J. Kelso

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Dipyridyl beta-diketonate complexes: versatile polydentate metalloligands for metal-organic frameworks and hydrogen-bonded networks, Andrew D. Burrows, Christopher G. Frost, Mary F. Mahon, Paul R. Raithby, Catherine L. Renouf, Christopher Richardson, and Anna J. Stevenson

Solid state interconversion of cages and coordination networks via conformational change of a semi-rigid ligand, Andrew Burrows, Christopher Frost, Mary Mahon, Paul Raithby, Christopher Richardson, and A. Stevenson

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Carboxymethylated-k-casein: A convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation, John A. Carver, Peter J. Duggan, Heath Ecroyd, Yanqin Liu, Adam G. Meyer, and C E. Tranberg

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Phytochemical investigations of Stemona curtisii and synthetic studies on stemocurtisine alkaloids, Sukanda Chaiyong, Araya Jatisatienr, Pitchaya Mungkornasawakul, Thanapat Sastraruji, Stephen G. Pyne, Alison T. Ung, Thitima Urathamakul, and Wilford Lie

P2X7 receptor activation induces cell death and microparticle release in murine erythroleukemia cells, Patrick Constantinescu, Bin Wang, Kati Kovacevic, Iman Jalilian, Giel J. Bosman, James S. Wiley, and Ronald Sluyter

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Distribution of class 1 integrons with IS26-mediated deletions in their 3'-conserved segments in Escherichia coli of human and animal origin., Fay E. Dawes, Alexander Kuzevski, Karl A Bettelheim, Michael A Hornitzky, Steven P Djordjevic, and Mark J. Walker

Sphingolipid distribution changes with age in the human lens, Jane Deeley, Joseph Hankin, Michael Friedrich, Robert Murphy, Roger J. W Truscott, Todd Mitchell, and Stephen J. Blanksby

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AlphaB-crystallin inhibits the cell toxicity associated with amyloid fibril formation by kappa-casein and the amyloid-beta peptide, Francis C. Dehle, Heath Ecroyd, Ian F. Musgrave, and John A. Carver

Complete assignment of the 1H and 13C NMR spectra of antimicrobial 4-arylamino- 3-nitrocoumarin derivatives, Vidoslav Dekic, Niko Radulovic, Rastko Vukicevic, Biljana Dekic, Danielle Skropeta, and Radosav Palic

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What is the mechanism for aripiprazole's effect on reducing olanzapine-associated obesity?, Chao Deng, J-Z Chen, Changhua Hu, and Xu-Feng Huang

Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia, Ania T. Deutscher, Cheryl Jenkins, F. Chris Minion, Lisa M. Seymour, Matthew P. Padula, Nicholas E. Dixon, Mark J. Walker, and Steven P. Djordjevic

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The two-faced nature of small heat shock proteins: amyloid assembly and the inhibition of fibril formation. Relevance to disease states, Heath W. Ecroyd, S Meehan, and John A. Carver

Imaging of human lens lipids by desorption electrospray ionization mass spectrometry, Shane Ellis, Chunping Wu, Jane Deeley, Xiangjia Zhu, Roger J. W Truscott, Marc in het Panhuis, R. Cooks, Todd Mitchell, and Stephen J. Blanksby

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Novel technique shows different hydrophobic chemical signatures of exotic and indigenous plant soils with similar effects of extracts on indigenous species seedling growth, Emilie-Jane Ens, Kristine O. French, John B. Bremner, and Jurgen Korth

P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells, Andrew Farrell, Safina Gadeock, Aleta Pupovac, Bin Wang, Iman Jalilian, Marie Ranson, and Ronald Sluyter

Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM), Mariana Figuera-Losada, Marie Ranson, Martina L. Sanderson-Smith, Mark J. Walker, Francis Castellino, and Mary Prorok

TGF-beta1 prevents up-regulation of the P2X7 receptor by IFN-gamma and LPS inleukemic THP-1 monocytes, Safina Gadeock, Jimmy Tran, Jennifer Georgiou, Iman Jalilian, Rosanne M. Taylor, James Wiley, and Ronald Sluyter

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Synthesis of reaction-ready 6,6 '-biindole and 6,6 '-biisatin via palladium(II)-catalysed intramolecular C-H functionalisation, Allan B. Gamble and Paul A. Keller

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Lipids and Alzheimer's disease, Brett Garner

Apolipoproteins in the brain: implications for neurological and psychiatric disorders, Brett Garner, David Elliott, and Cyndi Shannon Weickert

Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons, Brett Garner, H McCann, Glenda Halliday, K J Barnham, David Elliott, Woojin Scott Kim, Lotta Agholme, Katarina Kgedal, and Surabhi Bhatia

Synchrotron radiation infrared microspectroscopy of arsenic-induced changes to intracellular biomolecules in live leukemia cells, Kristie Gill, Keith Bambery, Elizabeth Carter, Ljiljana Puskar, Mark Tobin, Bayden Wood, and Carolyn T. Dillon

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Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition, Elias N. Glaros, Woojin Scott Kim, and Brett Garner

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A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives, Karina Gornall, Siritron Samosorn, Bongkot Tanwirat, Apichart Suksamrarn, John B. Bremner, Michael J. Kelso, and Jennifer L. Beck

The attempted stereoselective synthesis of chiral 2,2 '-biindoline, Mary Gresser, Steven Wales, and Paul A. Keller

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Structures, biological activities and phylogenetic relationships of Terpenoids from marine ciliates of the Genus Euplotes, Graziano Guella, Danielle Skropeta, Graziano Di Giuseppe, and Fernando Dini

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ESI-MS and thermal melting studies of nanoscale platinum(ii) metallomacrocycles with DNA, Margaret M. Harding, Louis M. Rendina, David Schilter, Thitima Urathamakul, and Jennifer L. Beck

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Equilibrium and kinetic modeling of the adsorption of indigo carmine onto silk, Naparat Jiwalak, Saowanee Rattanaphani, John B. Bremner, and Vichitr Rattanaphani

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Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes, Jodi A. Lee, David Croucher, and Marie Ranson

Transcriptome profiling of a TGF-beta-induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies, A. E. G. Lenferink; C. Cantin; A. Nantel; E. Wang; Y. Durocher; M. Banville,; B. Paul-Roc; A. Marcil; Mark R. Wilson; and M. D. O'Connor-McCourt

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Potential control of antipsychotic-induced hyperprolactinemia and obesity in children and adolescents by aripiprazole, J Lian, Xu-Feng Huang, Nagesh Pai, and Chao Deng

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Modulation of amyloid precursor protein processing by synthetic ceramide analogues, Hongyun Li, Woojin Scott Kim, Gilles Guillemin, Andrew F. Hill, Genevieve Evin, and Brett Garner

Understanding inflammatory pain: ion channels contributing to acute and chronic nociception, John E. Linley, Kirstin Rosen, Lezanne Ooi, and Nikita Gamper

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The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels, Boyi Liu, John E. Linley, Xiaona Du, Xuan Zhang, Lezanne Ooi, Hailin Zhang, and Nikita Gamper

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Parameters governing invasive disease propensity of non-M1 serotype Group A Streptococci, Peter G. Maamary, Martina L. Sanderson-Smith, Ramy K. Aziz, Andrew Hollands, Jason N. Cole, Fiona C. McKay, Jason D. McArthur, Joshua K. Kirk, Amanda J. Cork, Rachael J. Keefe, Rita G. Kansal, Hongmin Sun, William L. Taylor, Gursharan S. Chhatwal, David Ginsburg, Victor Nizet, Malak Kotb, and Mark J. Walker

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Synthesis of 2′-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities, Uta Mbere-Nguyen, Alison T. Ung, and Stephen G. Pyne

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Ultrasensitive detection of antibodies using a new Tus-Ter-lock immunoPCR system, Isabelle Morin, Nicholas E. Dixon, and Patrick M. Schaeffer

Hybrid methods for protein structure prediction, D. Mouradov, B. Kobe, Nicholas E. Dixon, and Thomas Huber

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Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability, Mariusz Mucha, Lezanne Ooi, John Linley, Pawel Mordaka, Carine Dalle, Brian Robertson, Nikita Gamper, and Ian C. Wood

The structure of Aspergillus niger phytase PhyA in complex with a phytate mimetic, Aaron Oakley

Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses., Aaron J. Oakley, Susan Barrett, Thomas Peat, Janet Newman, Victor Streltsov, Lynne Waddington, Takehiko Saito, Masato Tashiro, and Jennifer McKimm-Breschkin

Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism, Aaron J. Oakley, Marjorie Coggan, and Philip Board

A Single subunit directs the assembly of the escherichia coli DNA sliding clamp loader, Ah-Young Park, Slobodan Jergic, Argyris Politis, Brandon T. Ruotolo, Daniel Hirshberg, Linda L. Jessop, Jennifer L. Beck, Daniel Barsky, Mike O'Donnell, Nicholas E. Dixon, and Carol V. Robinson

Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro, Kara Perrow, Julie Locke, J. B. Bremner, Stephen G. Pyne, and Marie Ranson

Ozone-induced dissociation on a modified tandem linear ion-trap: observations of different reactivity for isomeric lipids, Berwyck L. Poad, Huong Thu Pham, Michael Thomas, Jessica R. Hughes, J Larry Campbell, Todd W. Mitchell, and Stephen J. Blanksby

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Nanometer-scale distance measurements in proteins using Gd3+ spin labeling, Alexey Potapov, Hiromasa Yagi, Thomas Huber, Slobodan Jergic, Nicholas E. Dixon, Gottfried Otting, and Daniella Goldfarb

Combining MBR and NF/RO membrane filtration for the removal of trace organics in indirect potable water reuse applications, William E. Price, Nichanan Tadkaew, Long D. Nghiem, Stuart Khan, Abdulhakeem Alturki, and James A. McDonald

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Average mass scan of the total ion chromatogram versus percentage chemical composition in multivariate statistical comparison of complex volatile mixtures, Niko Radulovic, Polina Blagojevic, and Danielle Skropeta

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Misidentification of tansy, tanacetum macrophyllum, as yarrow, achillea grandifolia: a health risk or benefit?, Niko Radulovic, Polina Blagojevic, Danielle Skropeta, Aleksandra Zarubica, Bojan Zlatkovic, and Radosav Palic´

Selectivity of externally facing ion-binding sites in the Na/K pump to alkali metals and organic cations, Ian M. Ratheal, Gail K. Virgin, Haibo Yu, Benoit Roux, Craig Gatto, and Pablo Artigas

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The interaction of unfolding α-lactalbumin and malate dehydrogenase with the molecular chaperone αB-crystallin: a light and X-ray scattering investigation, J W. Regini, Heath Ecroyd, Sarah Meehan, Kristen Bremmell, Matthew J. Clarke, Donna Lammie, Tim Wess, and John A. Carver

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Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities, Thunwadee Ritthiwigrom, Robert J. Nash, and Stephen G. Pyne

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Total synthesis of uniflorine A, casuarine, australine, 3-epi-australine, and 3,7-di-epi-australine from a common precursor, Thunwadee Ritthiwigrom, Anthony C. Willis, and Stephen G. Pyne

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Essential biological processes of an emerging pathogen: DNA replication, transcription, and cell division in Acinetobacter spp., Andrew Robinson, Anthony J. Brzoska, Kylie M. Turner, Ryan Withers, Elizabeth J. Harry, Peter J. Lewis, and Nicholas E. Dixon

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Assessing the accuracy of approximate treatments of ion hydration based on primitive quasichemical theory, Benoit Roux and Haibo Yu

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Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues, Kwankamol Sastraruji, Thanapat Sastraruji, Stephen G. Pyne, Alison T. Ung, Araya Jatisatienr, and Wilford Lie

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Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution, Jennifer Saville, Zhenjun Zhao, Mark D.P. Willcox, Stephen J. Blanksby, and Todd W. Mitchell

A processed multidomain Mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia, Lisa M. Seymour, Ania T. Deutscher, Cheryl Jenkins, Tracey A. Kuit, Linda Falconer, F. Chris Minion, Ben Crossett, Matthew Padula, Nicholas E. Dixon, Steven P. Djordjevic, and Mark J. Walker

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Learning how to be an academic - the story of a new academic in the sciences, Danielle Skropeta

Functional significance of P2RX7 polymorphisms associated with affective mood disorders, Ronald Sluyter, Leanne Stokes, Stephen Fuller, Kristen Skarratt, Ben Gu, and James Wiley

Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion, Leanne Stokes, Stephen Fuller, Ronald Sluyter, Kristen Skarratt, Ben Gu, and James Wiley

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Preclinical Evaluation of Novel All-in-one Formulations of 5-Fluorouracil and Folinic Acid with Reduced Toxicity Profiles - Supplementary Data, Tamantha K. Stutchbury, Kara L. Vine, Julie M. Locke, Jeremy S. Chrisp, J. B. Bremner, P Clingan, and Marie Ranson

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Localization of low molecular weight crystallin peptides in the aging human lens using a MALDI mass spectrometry imaging approach, S. P. Su, Jason D. McArthur, and J. A. Aquilina

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Copper-mediated cyclization-halogenation and cyclization-cyanation reactions of β-hydroxyalkynes and o-alkynylphenols and anilines, Nalivela K. Swamy, Arife Yazici, and Stephen G. Pyne

9th AINSE / ANBUG neutron scattering symposium, Moeava Tehei

Protein interactions and behaviour in multi-protein complexes, Moeava Tehei

Mapping protein dynamics conformational changes, Moeava Tehei, Flynn Hill, Charikleia Ioannou, M M Koza, and Nicholas E. Dixon

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Specific cellular water dynamics observed in vivo by neutron scattering and NMR., Moeava Tehei, Marion Jasnin, Andreas Stadler, and Giuseppe Zaccai

FTIR spectroscopy of single live cells in aqueous media by synchrotron IR microscopy using microfabricated sample holders, Mark Tobin, Ljiljana Puskar, Richard Barber, Erol Harvey, Philip Heraud, Bayden Wood, Keith Bambery, Carolyn T. Dillon, and Kristie Gill

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Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components, Danuta Tomkiewicz, Gabriele Casadei, Jonah Larkins-Ford, Terence I. Moy, James A. Garner, John B. Bremner, Frederik M. Ausubel, Kim Lewis, and Michael J. Kelso

Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors, Jimmy Tran, Aleta Pupovac, Rosanne M. Taylor, James Wiley, Scott Byrne, and Ronald Sluyter

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Hydration dependent studies of highly aligned multilayer lipid membranes by neutron scattering , Marcus Trapp, Thomas Gutberlet, Fanni Juranyi, T Unruh, Bruno Demé, Moeava Tehei, and Judith Peters

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Elastic scattering studies of aligned DMPC multilayers on different hydrations, Marcus Trapp, Fanni Juranyi, Moeava Tehei, Lambert van Eijck, Bruno Demé, Thomas Gutberlet, and Judith Peters

Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breat Cancer Metastasis, Joel Tyndall, Michael J. Kelso, and Marie Ranson

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The first syntheses of enantiopure 2,2 '-biindoline, Steven M. Wales, Anthony C. Willis, and Paul A. Keller

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The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation, Christopher A. Waudby, Tuomas P. J Knowles, Glyn L. Devlin, Jeremy N. Skepper, Heath Ecroyd, John A. Carver, Mark E. Welland, John Christodoulou, Christopher M. Dobson, and Sarah Meehan

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase, Jane Weber, Aaron J. Oakley, Angelika Christ, Alan Clark, John Hayes, Rhonda Hall, David Hume, Philip Board, Mark Smythe, and Jack Flanagan