Molecular Horizons - formerly the Centre for Medical and Molecular Bioscience (CMMB) - brings together a multidisciplinary team of chemists and biologists with a common interest in the molecular basis of disease and disease prevention from the School of Chemistry and School of Biological Sciences at the University of Wollongong.

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Papers from 2013

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The boronic acid Mannich reaction in alkaloid synthesis, Stephen G. Pyne, Andrew S. Davis, Thunwadee Ritthiwigrom, Christopher W. G Au, Kongdech Savaspun, and Matthew Wotherspoon

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Theoretical study on the ring-opening reactions of cyclopropenes mediated by a AuI complex, Nasir Ahmad Rajabi, Mona Jalali Atashgah, Rasool Babaahmadi, Christopher Hyland, and Alireza Ariafard

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Alkaloids from the roots and leaves of Stichoneuron halabalensis and their acetylcholinesterase inhibitory activities, Rosdayati Alino Ramli, Wilford Lie, and Stephen G. Pyne

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The association of antidepressant medication and body weight gain, Sara Ranjbar, Nagesh B. Pai, and Chao Deng

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Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins, Adel A. Rashad and Paul A. Keller

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Chemical constituents and biological activities of Garcinia cowa Roxb, Thunwadee Ritthiwigrom, Surat Laphookhieo, and Stephen G. Pyne

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype, Kate Roberts, Rafaa Zeineddine, Lisa Corcoran, Wen Li, Iain L. Campbell, and Justin J. Yerbury

Seven-membered rings, John H. Ryan, Christopher Hyland, Jeremy Just, Adam Meyer, Jason A. Smith, and Charlotte C. Williams

Bioactive compounds from the roots of Strophioblachia fimbricalyx, Prapairat Seephonkai, Stephen G. Pyne, Anthony C. Willis, and Wilford Lie

Fimbricalyx A, a novel phenanthrenone derivative having a rare 2H-benz[e]inden-2-one substructure, Prapairat Seephonkai, Stephen G. Pyne, Anthony C. Willis, and Wilford Lie

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Rapid cascade synthesis of poly-heterocyclic architectures from indigo, Alireza Shakoori Ghasabi, John Bremner, Anthony C. Willis, Rachada Haritakun, and Paul A. Keller

Model support studies toward the total synthesis of the stemona alkaloid stemocurtisine, Sudhir R. Shengule, Anthony C. Willis, and Stephen G. Pyne

Nrg1 mutation alters cytokine responses relevant to schizophrenia, P Snikeris, Xu-Feng Huang, and E Frank

Chronic inflammation alters production and release of glutathione and related thiols in human U373 astroglial cells, Megan L. Steele, Stacey Fuller, Annette E. Maczurek, Cindy Kersaitis, Lezanne Ooi, and Gerald Munch

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Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells, Megan L. Steele, Stacey Fuller, Mili Patel, Cindy Kersaitis, Lezanne Ooi, and Gerald Munch

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Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells, Megan L. Steele, John Truong, Suresh Govindaraghavan, Lezanne Ooi, Nikolaus J. Sucher, and Gerald Munch

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Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells, Vinod Sundaramoorthy, Adam K. Walker, Justin J. Yerbury, Kai Ying Soo, Manal A. Farg, Vy Hoang, Rafaa Zeineddine, Damian Spencer, and Julie D. Atkin

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Bacterial filtration using carbon nanotube/antibiotic buckypaper membranes, Luke J. Sweetman, Leighton J. Alcock, Jason D. McArthur, Elise M. Stewart, Gerry Triani, Marc in het Panhuis, and Stephen F. Ralph

High hydrostatic pressure effects investigated by neutron scattering on lipid multilamellar vesicles, Marcus Trapp, Jeremie Marion, Moeava Tehei, Bruno Deme, Thomas Gutberlet, and Judith Peters

Relation between dynamics, activity and thermal stability within the cholinesterase family, Marie Trovaslet, Marcus Trapp, Martin Weik, Florian Nachon, Patrick Masson, Moeava Tehei, and Judith Peters

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Inhibition of P-glycoprotein mediated multidrug resistance by stemofoline derivatives, Sonthaya Umsumarng, Komsak Pintha, Pornsiri Pitchakarn, Kwankamol Sastraruji, Thanapat Sastraruji, Alison T. Ung, Araya Jatisatienr, Stephen G. Pyne, and Pornngarm Limtrakul

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Synthesis and inhibitory activities at mGluRs of 3-alkylated and N-alkylated cyclopentyl-glutamate analogues, Alison T. Ung, Stephen G. Pyne, Francois Bischoff, Anne S. J Lesage, Brian W. Skelton, and Allan H. White

Asymmetric synthesis of indole homo-michael adducts via dynamic kinetic friedel-crafts alkylation with cyclopropanes, Steven M. Wales, Morgan M. Walker, and Jeffrey S. Johnson

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P2X7 receptor activation induces reactive oxygen species formation in erythroid cells, Bin Wang and Ronald Sluyter

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Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Jurgen Korth, - Samten, Malai Taweechotipatr, Roonglawan Rattanajak, and Sumalee Kamchonwongpaisan

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A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Wilford Lie, Anthony C. Willis, Roonglawan Rattanajak, and Sumalee Kamchonwongpaisan

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Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, and Malai Taweechotipatr

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GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Malai Taweechotipatr, and Sumalee Kamchonwongpaisan

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An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: textual understanding and the current practices, Phurpa Wangchuk, Stephen G. Pyne, and Paul A. Keller

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Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease, Yuan Min Wang, Jimmy Jianheng Zhou, Ya Wang, Debbie Watson, Geoff Yu Zhang, Min Hu, Huiling Wu, Guoping Zheng, Yiping Wang, Anne M. Durkan, David CH Harris, and Stephen I. Alexander

Avoidance of contaminated sediments by an amphipod (Melita plumulosa), a harpacticoid copepod (Nitocra spinipes), and a snail (Phallomedusa solida), Daniel J. Ward, Stuart L. Simpson, and Dianne F. Jolley

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Slow avoidance response to contaminated sediments elicits sublethal toxicity to benthic invertebrates, Daniel J. Ward, Stuart L. Simpson, and Dianne F. Jolley

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The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil, Clare A. Watson, Kara L. Vine, Julie M. Locke, Anna Bezos, Christopher R. Parish, and Marie Ranson

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Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia, C S. Weickert, S J. Fung, V S. Catts, P R. Schofield, K M. Allen, L T. Moore, Kelly A. Newell, D Pellen, Xu-Feng Huang, S V. Catts, and T W Weickert

Binding affinity of aripiprazole to the dopamine D2 receptor in different regions of the rat brain, Katrina Weston-Green and Chao Deng

Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor, Katrina Weston-Green, Xu-Feng Huang, and Chao Deng

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Parviflorals A-F, trinorcadalenes and bis-trinorcadalenes from the roots of Decaschistia parviflora, Nikhom Wongsa, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Palangpon Kongsaeree, Samran Prabpai, and Stephen G. Pyne

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Concise synthesis of α-substituted 2-benzofuranmethamines and other 2-subsituted benzofurans via α-substituted 2-benzofuranmethyl carbocation intermediates, Nikhom Wongsa, Ubonta Sommart, Thunwadee Ritthiwigrom, Arife Yazici, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Anthony C. Willis, and Stephen G. Pyne

Teasaponin improves central leptin sensitivity in high-fat diet-induced obese mice, Y Z. Wu, Xu-Feng Huang, and Y H. Yu

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Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms, Amy R. Wyatt, Patrick Constantinescu, Heath Ecroyd, Christopher M. Dobson, Mark R. Wilson, Janet R. Kumita, and Justin J. Yerbury

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Acute phase proteins are major clients for the chaperone action of α2-macroglobulin in human plasma, Amy R. Wyatt and Mark R. Wilson

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Extracellular chaperones and proteostasis, Amy R. Wyatt, Justin J. Yerbury, Heath Ecroyd, and Mark R. Wilson

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Removal of trace organic contaminants by nitrifying activated sludge and whole-cell and crude enzyme extract of Trametes versicolor, Shufan Yang, Faisal I. Hai, Long D. Nghiem, Felicity Roddick, and William E. Price

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Sequential 1,4- and 1,2-addition reactions to α,β-unsaturated N-acyliminium ions: a new strategy for the synthesis of spiro and bridged heterocycles, Arife Yazici and Stephen G. Pyne

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Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase, Nageshwar Rao Yepuri, Nicolas Barraud, Nasim Shah Mohammadi, Bharat G. Kardak, Staffan Kjelleberg, Scott A. Rice, and Michael J. Kelso

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The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro, Justin J. Yerbury, Dane Gower, Laura Vanags, Kate Roberts, Jodi A. Lee, and Heath Ecroyd

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Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp, Zhou Yin, Michael J. Kelso, Jennifer L. Beck, and Aaron J. Oakley

Time-dependent ghrelinergic signaling and hyperphagia induced by olanzapine, Q Zhang, M He, J Lian, C Deng, and Xu-Feng Huang

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The role of ghrelin signalling in second-generation antipsychotic-induced weight gain, Qingsheng Zhang, Chao Deng, and Xu-Feng Huang

Papers from 2012

Photo-tautomerization of acetaldehyde to vinyl alcohol: A potential route to tropospheric acids, D Andrews, B Heazlewood, Alan T. Maccarone, T Conroy, R Payne, Meredith J. T Jordan, and Scott Kable

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Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content, Hanna Appelqvist, Linnea Sandin, Karin Bjornstrom, Paul Saftig, Brett Garner, Karin ollinger, and Katarina Kagedal

Predictors of telomere content in dragon lizards, Cissy Ballen, Mo Healey, Mark Wilson, Michael Tobler, and Mats Olsson

Net superoxide levels: steeper increase with activity in cooler female and hotter male lizards, Cissy Ballen, Mo Healey, Mark Wilson, Michael Tobler, Erik Wapstra, and Mats Olsson

Cephalosporin-3'-diazeniumdiolates:Targeted NO-donor prodrugs for dispersing bacterial biofilms, Nicolas Barraud, Bharat G. Kardak, Nageshwar R. Yepuri, Robert p. Howlin, Jeremy S. Webb, Saul N. Faust, Staffan Kjelleberg, Scott A. Rice, and Michael J. Kelso

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Inorganic arsenic and iron(II) distributions in sediment porewaters investigated by a combined DGT - colourimetric DET technique, William Bennett, Peter R. Teasdale, David T. Welsh, Jarad Panther, Ryan R. Stewart, Helen L. Price, and Dianne F. Jolley

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Investigating arsenic speciation and mobilization in sediments with DGT and DET: a mesocosm evaluation of oxic-anoxic transitions, William W. Bennett, Peter R. Teasdale, Jarad G. Panther, David T. Welsh, Huijun Zhao, and Dianne F. Jolley

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Optimization of colorimetric DET technique for the in situ, two-dimensional measurement of iron(II) distributions in sediment porewaters, William W. Bennett, Peter R. Teasdale, David T. Welsh, Jarad G. Panther, and Dianne F. Jolley

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Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease, Surabhi Bhatia, Bianca Knoch, Jenny Wong, Woojin Scott Kim, Paul Else, Aaron J. Oakley, and Brett Garner

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Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which Mycoplasma hyopneumoniae regulates surface topography, Daniel Bogema, Ania T. Deutscher, Lauren K. Woolley, Lisa M. Seymour, Benjamin B. A Raymond, Jessica L. Tacchi, Matthew P. Padula, Nicholas E. Dixon, F Chris Minion, Cheryl Jenkins, Mark J. Walker, and Steven P. Djordjevic

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Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations, John Bremner, Paul A. Keller, Stephen Pyne, Mark Robertson, Kandasamy Sakthivel, Kittiya Somphol, Dean Baylis, Jonathon A Coates, John Deadman, Dharshini Jeevarajah, and David I. Rhodes

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Automated surface sampling of lipids from worn contact lenses coupled with tandem mass spectrometry, Simon H. Brown, Liam H. Huxtable, Mark D. P Willcox, Stephen J. Blanksby, and Todd W. Mitchell

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The synthesis, structures and reactions of zinc and cobalt metal-organic frameworks incorporating an alkyne-based dicarboxylate linker, Andrew D. Burrows, L C. Fisher, David M. Hodgson, Mary F. Mahon, Naomi Cessford, Tina Duren, Christopher Richardson, and S P. Rigby

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Fragment-based screening by protein crystallography: successes and pitfalls, Zorik Chilingaryan, Zhou Yin, and Aaron J. Oakley

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Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics - implications for pathogenesis, Simon M. Cook, Amanda Skora, Christine M. Gillen, Mark J. Walker, and Jason D. McArthur

The contribution of proteomics to understanding epididymal maturation of mammalian spermatozoa, Jean-Louis Dacheux, Clemence Belleannee, Benoit Guyonnet, Valerie Labas, Ana-Paula Teixeira-Gomes, Heath Ecroyd, Xavier Druart, Jean-Luc Gatti, and Francoise Dacheux

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Does cytotoxicity of metallointercalators correlate with cellular uptake or DNA affinity?, Kimberley J. Davis, Judith A. Carrall, Barry Lai, Janice R. Aldrich-Wright, Stephen F. Ralph, and Carolyn T. Dillon

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Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an hemolytic Escherichia coli O108:H-human clinical isolate, Fay E. Dawes, Dieter M. Bulach, Alexander Kuzevski, Karl A. Bettelheim, Carola Venturini, Steven P. Djordjevic, and Mark J. Walker

Effects of dopamine D2 receptor partial agonist bifeprunox on body weight gain, food and water intake in male rats, M B. De Santis, Xu-Feng Huang, and C Deng

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Synchrotron radiation spectroscopic techniques as tools for the medicinal chemist: microprobe X-Ray fluorescence imaging, X-Ray absorption spectroscopy, and infrared microspectroscopy, Carolyn Therese Dillon

A new role for the proofreader in bacterial DNA replication, Nicholas E. Dixon and Slobodan Jergic

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P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells, Safina Gadeock, Aleta Pupovac, Vanessa Sluyter, Mari Spildrejorde, and Ronald Sluyter

Evidence that truncated TrkB isoform, TrkB-Shc can regulate phosphorylated TrkB protein levels, Brett Garner and Jenny Wong

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Gender differences in cognitive function of patients with chronic schizophrenia, Mei Han, Xu-Feng Huang, Da Chun Chen, Mei Hong Xiu, Li Hui, Haibo Liu, Thomas R. Kosten, and Xiang Yang Zhang

A comparison of three molecular markers for the identification of populations of Globodera pallida, Angelique H. Hoolahan, Vivian C. Blok, Tracey Gibson, and Mark Dowton

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Membrane lipids in human lenses and age, J R. Hughes, J M. Deeley, J -A Seng, S R. Ellis, Stephen J. Blanksby, F Leisch, Roger J. W Truscott, and T W. Mitchell

Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor, Vineesh Indira Chandran, Lidia Matesic, Julie M. Locke, Danielle Skropeta, Marie Ranson, and Kara L. Vine

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Novel olanzapine analogues presenting a reduced H1 receptor affinity and retained 5HT2A/D2 binding affinity ratio, Somayeh Jafari, Marc E. Bouillon, Xu-Feng Huang, Stephen G. Pyne, and Francesca Fernandez-Enright

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Activation of the damage-associated molecular pattern receptor P2X7 induces interleukin-1B release from canine monocytes, Iman Jalilian, Michelle Peranec, Belinda L. Curtis, Aine Seavers, Mari Spildrejorde, Vanessa Sluyter, and Ronald Sluyter

Metabotropic glutamate receptor subtype 5 is reduced in schizophrenia subjects with comorbid major depression and unchanged following antipsychotic drug treatment, N Jimenez, Xu-Feng Huang, C Deng, and K Newell

The therapeutic potential of the endocannabinoid system for Alzheimer's disease, Tim Karl, David Cheng, Brett Garner, and Jonathon C. Arnold

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Chemical constituents and antioxidant and biological activities of the essential oil from leaves of Solanum spirale, Sukanya Keawsa-Ard, Boonsom Liawruangrath, Saisunee Liawruangrath, Aphiwat Teerawutgulrag, and Stephen G. Pyne

Anticancer and antibacterial activities of the isolated compounds from Solanum spirale Roxb. leaves, Sukanya Keawsa-ard, Surapol Natakankitkul, Saisunee Liawruangrath, Aphiwat Teerawutkulrag, Kongkiat Trisuwan, Patchanee Charoenying, Stephen G. Pyne, and Boonsom Liawruangrath

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Gelapin, a degradable genipin cross-linked gelatin hydrogel, Damian Kirchmajer, C Watson, Marie Ranson, and Marc in het Panhuis

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The small heat-shock protein αB-crystallin uses different mechanisms of chaperone action to prevent the amorphous versus fibrillar aggregation of α-lactalbumin, Melissa Kulig and Heath Ecroyd

Impact of copper exposure on Pseudo-nitzschia spp. physiology and domoic acid production, Aurelle Lelong, Dianne F. Jolley, Philippe Soudant, and Helene Hegaret

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Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues, Hongyun Li, Genevieve Evin, Andrew F. Hill, Ya Hui HUNG, Ashley I. BUSH, and Brett Garner

Bioinspired self-assembly I: self-assembled structures, Leonard F. Lindoy, Christopher Richardson, and Jack K. Clegg

Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons, John E. Linley, Lezanne Ooi, Louisa Pettinger, Hannah Kirton, John P. Boyle, Chris Peers, and Nikita Gamper

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Simulation study of ion pairing in concentrated aqueous salt solutions with a polarizable force field, Yun Luo, Wei Jiang, Haibo Yu, Alexander D. Mackerrell, and Benoit Roux

Priming the engine of DNA synthesis, Robyn E. Mansfield and Nicholas E. Dixon

Backbone assignment of fully protonated solid proteins by 1H detection and ultrafast magic-angle-spinning NMR spectroscopy, Alessandro Marchetti, Stefan Jehle, Michele Felletti, Michael J. Knight, Yao Wang, Zhi-Qiang Xu, Ah-Young Park, Gottfried Otting, Anne Lesage, Lyndon Emsley, Nicholas E. Dixon, and Guido Pintacuda

Polyelectrolyte complex materials consisting of antibacterial and cell-supporting layers, Khairul Anuar Mat Amin, Kerry J. Gilmore, Jake Matic, Stephen Poon, Mark J. Walker, Mark R. Wilson, and Marc in het Panhuis

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Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, and Danielle Skropeta

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The role of streptokinase as a virulence determinant of streptococcus pyogenes - potential for therapeutic targeting, Jason D. McArthur, Simon M. Cook, Carola Venturini, and Mark J. Walker

Notes on the distribution of 31 species of Sarcophagidae (Diptera) in Australia, including new records in Australia for eight species, Kelly A. Meiklejohn, Mark Dowton, and James F. Wallman

Comprehensive evaluation of DNA barcoding for the molecular species identification of forensically important Australian Sarcophagidae (Diptera), Kelly A. Meiklejohn, James F. Wallman, Stephen L. Cameron, and Mark Dowton

Structural lipidomics, Todd W. Mitchell, Simon H. J Brown, and Stephen J. Blanksby

The effects of phencyclidine treatment on the nmdar-nrg1 signalling pathway in rats, T Morosin, T M. Du Bois, K A. Newell, and Xu-Feng Huang

Using X-ray absorption spectroscopy and microprobe synchrotron radiation-X-ray fluorescence imaging for understanding the mode of action of arsenic anti-leukaemia agents, Kristie Munro, Carolyn T. Dillon, H H, Z. Cai, B. Lai, S Vogt, and M Cheah

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The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-beta 1-40 peptide, Priyanka Narayan, Angel Orte, Richard W. Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A. Ganzinger, Sarah Meehan, Mark R. Wilson, Christopher M. Dobson, and David Klenerman