The Centre for Medical and Molecular Bioscience (CMMB) brings together a multidisciplinary team of chemists and biologists with a common interest in the molecular basis of disease and disease prevention from the School of Chemistry and School of Biological Sciences at the University of Wollongong.

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Papers from 2014

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Diffusive gradients in thin films technique provide robust prediction of metal bioavailability and toxicity in estuarine sediments, Elvio D. Amato, Stuart Simpson, Chad Jarolimek, and Dianne Jolley

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Novel implications of lingo-1 signaling in the post-mortem schizophrenia brain, Jessica Andrews, Kelly Newell, Xu-Feng Huang, and Francesca Fernandez-Enright

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Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands, Mark E. Ashford, Vu H. Nguyen, Ivan Greguric, Tien Q. Pham, Paul A. Keller, and Andrew Katsifis

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Carbazole alkaloids and coumarins from the roots of Clausena guillauminii, Chiramet Auranwiwat, Surat Laphookhieo, Kongkiat Trisuwan, Stephen G. Pyne, and Thunwadee Ritthiwigrom

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The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease, Rachael Bartlett, Leanne Stokes, and Ronald Sluyter

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Roadblocks on the E.Coli genome: the Workings of a molecular mouse trap at the single-molecule level, Bojk A. Berghuis, David Dulin, Bronwen Cross, Nicholas Dixon, and Nynke H. Dekker

Diastereoselective concise syntheses of the polyhydroxylated alkaloids DMDP and DAB, Marc Bouillon and Stephen G. Pyne

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Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells, Chao Chen, Naveen K. Dolla, Gabriele Casadei, John B. Bremner, Kim Lewis, and Michael J. Kelso

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Factors governing the rejection of trace organic contaminants by nanofiltration and reverse osmosis membranes, Hai Q. Dang, Long D. Nghiem, and William E. Price

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Binding interactions between nickel schiff base complexes and quadruplex DNA, Kimberley Jane Davis, Christopher Richardson, Jennifer Beck, and Stephen Frederick Ralph

Oxygen binding sites in obelin: a computational study into the formation of active photoproteins, Thomas M. Griffiths and Haibo Yu

Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages, Dhanushka Gunawardena, Louise Bennett, Kirubakaran Shanmugam, Kerryn King, Roderick Williams, Dimitrios Zabaras, Richard Head, Lezanne Ooi, Erika Gyengesi, and Gerald Münch

Biological evaluation of bismuth non-steroidal anti-inflammatory drugs (BiNSAIDs): stability, toxicity and uptake in HCT-8 colon cancer cells, Emma Hawksworth, Philip C. Andrews, Wilford Lie, Barry Lai, and Carolyn Dillon

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The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity, Georg K. A Hochberg, Heath Ecroyd, Cong Liu, Dezerae Cox, Duilio Cascio, Michael Sawaya, Miranda Collier, James Stroud, John A. Carver, Andrew Baldwin, Carol Robinson, David Eisenberg, Justin Benesch, and Arthur Laganowsky

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Polyunsaturated fats, membrane lipids and animal longevity, Anthony J. Hulbert, Megan A. Kelly, and Sarah K. Abbott

Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis, James E. Kath, Slobodan Jergic, Justin M. H Heltzel, Deena T. Jacob, Nicholas Dixon, Mark D. Sutton, Graham C. Walker, and Joseph J. Loparo

Coexistence of minicircular and a highly rearranged mtDNA molecule suggests that recombination shapes mitochondrial genome organization, Meng Mao, Andrew D. Austin, Norman F. Johnson, and Mark Dowton

Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage, Priyanka Narayan, Kira M. Holmstrom, Dong-Hyun Kim, Daniel J. Whitcomb, Mark Wilson, Peter St George-Hyslop, Nicholas W. Wood, Christopher M. Dobson, Kwangwook Cho, Andrey Y. Abramov, and David Klenerman

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Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics, Kelly A. Newell and Natalie Matosin

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Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus, Phuong Nguyen, Haibo Yu, and Paul Keller

Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics, Huong T. Pham, Alan T. Maccarone, Michael C. Thomas, J Larry Campbell, Todd W. Mitchell, and Stephen J. Blanksby

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Simultaneous nitrification/denitrification and trace organic contaminant (TrOC) removal by an anoxic-aerobic membrane bioreactor (MBR), Hop Phan, Faisal Ibney Hai, Jinguo Kang, Hoa Dam, Ren Zhang, William Price, Andreas Broeckmann, and Long Nghiem

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell, Saskia Polling, Yee-Foong Mok, Yasmin Ramdzan, Bradley J. Turner, Justin J. Yerbury, Andrew Hill, and Danny M. Danny

The boronic acid Mannich reaction, Stephen G. Pyne and Minyan Tang

Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities, Rosdayati Alino Ramli, Wilford Lie, and Stephen G. Pyne

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Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei, Adel Rashad, Amy J. Jones, Vicky M. Avery, Jonathan Baell, and Paul Keller

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Chikungunya virus: emerging targets and new opportunities for medicinal chemistry, Adel Rashad, Suresh Mahalingam, and Paul Keller

Clostridium difficile infection: molecular pathogenesis and novel therapeutics, Ardeshir Rineh, Michael J. Kelso, Fatma Vatansever, George P. Tegos, and Michael R. Hamblin

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Total synthesis of hyacinthacines B3, B4, and B 5 and purported hyacinthacine B7, 7-epi-hyacinthacine B7, and 7a-epi-hyacinthacine B3 from a common precursor, Kongdech Savaspun, Christopher W. G Au, and Stephen G. Pyne

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Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy, Dmitry Shishmarev, Yao Wang, Claire Mason, Xun-Cheng Su, Aaron Oakley, Bim Graham, Thomas Huber, Nicholas Dixon, and Gottfried Otting

Antibacterial anthranilic acid derivatives from Geijera parviflora, Qingyao Shou, Linda K. Banbury, Alan T. Maccarone, Dane E. Renshaw, Htwe Mon, Stefani Griesser, Hans J. Griesser, Stephen J. Blanksby, Joshua E. Smith, and Hans Wohlmuth

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Fullerene van der Waals oligomers as electron traps, Tatyana E. Shubina, Dmitry I. Sharapa, Christina Schubert, Dirk Zahn, Marcus Halik, Paul Keller, Stephen G. Pyne, Sreenu Jennepalli, Dirk Guldi, and Timothy Clark

Metal speciation and potential bioavailability changes during discharge and neutralisation of acidic drainage water, Stuart Simpson, Christopher R. Vardanega, Chad Jarolimek, Dianne Jolley, Brad M. Angel, and Luke M. Mosley

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T Cells continue to play on the ATP circuit, Ronald Sluyter and Debbie Watson

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P2X7 receptor activation induces CD62L shedding from human CD4+ and CD8+ T cells, Ronald Sluyter and James S. Wiley

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The use of immobilised metal affinity chromatography (IMAC) to compare expression of copper-binding proteins in control and copper-exposed marine microalgae, Cassandra L. Smith, Jenny L. Stauber, Mark R. Wilson, and Dianne F. Jolley

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Extracellular adenosine 5'-triphosphate and lipopolysaccharide induce interleukin-1β release in canine blood, Mari Spildrejorde, Stephen J. Curtis, Belinda L. Curtis, and Ronald Sluyter

Bound or free: interaction of the C-terminal domain of Escherichia coli single-stranded DNA-binding protein (SSB) with the tetrameric core of SSB, Xun-Cheng Su, Yao Wang, Hiromasa Yagi, Dmitry Shishmarev, Claire Mason, Paul J. Smith, Marylene Vandevenne, Nicholas Dixon, and Gottfried Otting

Transforming growth factor beta (TGFβ) plays a crucial role in prolonging allograft survival in an allodepletion ("pruning") skin transplant model, Debbie Watson, Geoff Yu Zhang, Min Hu, Yuan-Min Wang, Jeffery Fletcher, Mary Sartor, and Stephen I. Alexander

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Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin, Amy Wyatt, Janet Kumita, Richard W. Mifsud, Cherrie A. Gooden, Mark Wilson, and Christopher M. Dobson

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DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs, Zhou Yin, Yao Wang, Louise Whittell, Slobodan Jergic, Michael Liu, Elizabeth J. Harry, Nicholas Dixon, Michael Kelso, Jennifer Beck, and Aaron Oakley

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Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach, Zhou Yin, Louise Whittell, Yao Wang, Slobodan Jergic, Michael Liu, Elizabeth J. Harry, Nicholas Dixon, Jennifer Beck, Michael Kelso, and Aaron Oakley

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PKa cycling of the general acid/base in glycoside hydrolase families 33 and 34, Haibo Yu and Thomas M. Griffiths

Papers from 2013

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P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia, Rachael Bartlett, Justin J. Yerbury, and Ronald Sluyter

Leptin signalling in the dorsal vagal complex and ventrolateral medulla with age and high-fat diet induced obesity, C Bell, Y H. Yu, A Szabo, and Xu-Feng Huang

Avoiding the oligomeric state: αB-crystallin inhibits fragmentation and induces dissociation of apolipoprotein C-II amyloid fibrils, Katrina J. Binger, Heath Ecroyd, Shuo Yang, John A. Carver, Geoffrey J. Howlett, and Michael D. W Griffin

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Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of a non-catalytic ligandin site, Joseph Brock, Philip G. Board, and Aaron J. Oakley

Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs, Simon H. J Brown, Cecilia Y. Cheng, S Adrian Saldanha, Jian Wu, Howard B. Cottam, Banumathi Sankaran, and Susan S. Taylor

The therapeutic effects of an oleanolic acid derivative in diet induced obesity, D Camer, Xu-Feng Huang, and Y Yu

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Extracellular chaperones prevent Aβ42-induced toxicity in rat brains, Roberta Cascella, Simona Conti, Francesca Tatini, Elisa Evangelisti, Tania Scartabelli, Fiorella Casamenti, Mark R. Wilson, Fabrizio Chiti, and Cristina Cecchi

Central administrations of palmitic acid and arachidonic acid decrease central leptin sensitivity in mice, L Cheng, Xu-Feng Huang, and Y Yu

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Mechanism for the synergistic effect of rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B, J Chen and Xu-Feng Huang

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Developing Galleria mellonella as a model host for human pathogens, Simon M. Cook and Jason D. McArthur

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Extracellular chaperones, Rebecca A. Dabbs, Amy R. Wyatt, Justin J. Yerbury, Heath Ecroyd, and Mark R. Wilson

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Allosteric activation transitions in enzymes and biomolecular motors: insights from atomistic and coarse-grained simulations, Michael D. Daily, Haibo Yu, George N. Phillips, and Qiang Cui

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Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway, Chao Deng, Bo Pan, Martin Engel, and Xu-Feng Huang

Effects of chronic antipsychotic treatment on dopamine synthesis, M De Santis, Xu-Feng Huang, A Jenner, and C Deng

Amyloid fibrils from readily available sources: milk casein and lens crystallin proteins, Heath Ecroyd, Megan Garvey, David C. Thorn, Juliet A. Gerrard, and John A. Carver

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Synthesis of spirocyclopente-dione anthracene adduct, precursor of the cyclopentenone prostagladins via ring-closing metathesis reaction, Gedsirin Eksinitkun, Stephen G. Pyne, Waya S. Phutdhawong, and Weerachai Phutdhawong

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Surface analysis of lipids by mass spectrometry: more than just imaging, Shane R. Ellis, Simon H. Brown, Marc in het Panhuis, Stephen J. Blanksby, and Todd W. Mitchell

Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment, Georgia Frangioudakis, Barbara Diakanastasis, Bing-Qing M. Liao, Jennifer T. Saville, Nolan J. Hoffman, Todd W. Mitchell, and Carsten Schmitz-Peiffer

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Diabetes and cognitive deficits in chronic schizophrenia: a case-control study, Mei Han, Xu-Feng Huang, Da Chun Chen, Meihong Xiu, Thomas R. Kosten, and Xiang Yang Zhang

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The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain, Meng He, Chao Deng, and Xu-Feng Huang

Central administration of histamine H1 receptor agonist, fMPH, blocks olanzapineinduced activation of ampk-cpt1 signaling in the dorsal vagal complex in rats, M He, Q Zhang, H Wang, C Deng, and Xu-Feng Huang

Dengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis, Lara J. Herrero, Andrew Zakhary, Michelle E. Gahan, Michelle A. Nelson, Belinda L. Herring, Andrew J. Hapel, Paul A. Keller, Maheshi Obeysekera, Weiqiang Chen, Kuo-Ching Sheng, Adam Taylor, Stefan Wolf, Jayaram Bettadapura, Shobha Broor, Lalit Dar, and Suresh Mahalingam

Controlled oxidation of pyrroles: synthesis of highly functionalized γ-lactams, James Howard, Christopher Hyland, Jeremy Just, and Jason A. Smith

Secondary vitellogenesis persists despite disrupted fecundity in amphipods maintained on metal-contaminated sediment: X-ray fluorescence assessment of oocyte metal content, Ross V. Hyne, Reinier M. Mann, Carolyn T. Dillon, Martin D. de Jonge, David Paterson, and Daryl L. Howard

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Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities, Nadechanok Jiangseubchatveera, Marc E. Bouillon, Boonsom Liawruangrath, Saisunee Liawruangrath, Robert J. Nash, and Stephen G. Pyne

Virtual screening identifies lupeol as an allosteric inhibitor of PTP1B, T T. Jin, H B. Yu, and Xu-Feng Huang

Replicative DNA polymerases, Erik Johansson and Nicholas Dixon

Ring synthesis, Paul A. Keller, Mohammed K. Abdel-Hamid, and Ashraf M. Abdel-Megeed

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Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease, Woojin S. Kim, Hongyun Li, Kalani Ruberu, Sharon Chan, David A. Elliott, Jac Kee Low, David Cheng, Tim Karl, and Brett Garner

Long term effects of olanzapine and betahistine on serotonin 5-HT2A receptor binding in the rat brain, J Lian, Xu-Feng Huang, and C Deng

Subchronic metabotropic glutamate 5 receptor modulation in the perinatal pcp rodent model of schizophrenia, J S. Lum, E Frank, N Matosin, Xu-Feng Huang, and K A. Newell

Direct observation of photodissociation products from phenylperoxyl radicals isolated in the gas phase, Alan T. Maccarone, Benjamin B. Kirk, Christopher S. Hansen, Thomas M. Griffiths, Seth Olsen, Adam J. Trevitt, and Stephen J. Blanksby

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Generation of hydrogen peroxide-resistant murine neuroblastoma cells: a target discovery platform for novel neuroprotective genes, Annette E. Maczurek, Rebekka Wild, Daunia Laurenti, Megan L. Steele, Lezanne Ooi, and Gerald Munch

Association of a GRIA3 gene polymorphism with migraine in an Australian case-control cohort, Bridget H. Maher, Rod A. Lea, Jordan Follett, Hanna C. Cox, Francesca E. Fernandez, Teresa Esposito, Fernando Gianfrancesco, Larisa M. Haupt, and Lyn R. Griffiths

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Escherichia coli single-stranded DNA-binding protein: nanoESI-MS studies of salt-modulated subunit exchange and DNA binding transactions, Claire E. Mason, Slobodan Jergic, Allen Lo, Yao Wang, Nicholas E. Dixon, and Jennifer L. Beck

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Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment, Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang, and Kelly A. Newell

Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia, Natalie Matosin and Kelly A. Newell

An analysis of metabotropic glutamate receptors 2/3 and 5 in schizophrenia, major depression and bipolar disorder from the stanley neuropathology consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, and K A. Newell

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Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis, Luke McAlary, Justin J. Yerbury, and J. Andrew Aquilina

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Bioassays for anticancer activities, Janice McCauley, Ana Zivanovic, and Danielle Skropeta

A key to the Australian Sarcophagidae (Diptera) with special emphasis on Sarcophaga (sensu lato), Kelly A. Meiklejohn, Mark Dowton, Thomas Pape, and James F. Wallman

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DNA barcoding identifies all immature life stages of a forensically important flesh fly (Diptera: Sarcophagidae), Kelly A. Meiklejohn, James F. Wallman, and Mark Dowton

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Utility of COI, CAD and morphological data for resolving relationships within the genus Sarcophaga (sensu lato) (Diptera: Sarcophagidae): a preliminary study, Kelly A. Meiklejohn, James F. Wallman, Thomas Pape, Stephen L. Cameron, and Mark Dowton

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6-Hydroxy-5,6-seco-stemocurtisine: a novel seco-stemocurtisine-type alkaloid, Pitchaya Mungkornasawakul, Stephen G. Pyne, Anthony C. Willis, Araya Jatisatienr, Duang Phuthsuk, and Wilford Lie

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Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells, Priyanka Narayan, Kristina A. Ganzinger, James Mccoll, Laura Weimann, Sarah Meehan, Seema Qamar, John A. Carver, Mark R. Wilson, Peter St George-Hyslop, Christopher M. Dobson, and David Klenerman

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Short-term effects of fish and fish oil consumption on total and high molecular weight adiponectin levels in overweight and obese adults, Elizabeth P. Neale, Beverly Muhlhausler, Yasmine C. Probst, Marijka J. Batterham, Francesca Fernandez, and Linda C. Tapsell

A neuregulin 1 transmembrane domain mutation causes imbalanced glutamatergic and dopaminergic receptor expression in mice, K A. Newell, T Karl, and Xu-Feng Huang

Constituents of the Indonesian Epiphytic Medicinal Plant Drynaria rigidula, Ari S. Nugraha, Rachada Haritakun, and Paul A. Keller

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Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species, Lezanne Ooi, Sylvain Gigout, Louisa Pettinger, and Nikita Gamper

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Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, and Gerald Munch

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Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, ε, θ and β reveals a highly flexible arrangement of the proofreading domain, Kiyoshi Ozawa, Nicholas P. Horan, Andrew Robinson, Hiromasa Yagi, Flynn R. Hill, Slobodan Jergic, Zhi-Qiang Xu, Karin V. Loscha, Nan Li, Moeava Tehei, Aaron J. Oakley, Gottfried Otting, Thomas Huber, and Nicholas E. Dixon

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Ozone-induced dissociation of conjugated lipids reveals significant reaction rate enhancements and characteristic odd-electron product ions, Huong T. Pham, Alan T. Maccarone, J Larry Campbell, Todd W. Mitchell, and Stephen J. Blanksby

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Rapid differentiation of isomeric lipids by photodissociation mass spectrometry of fatty acid derivatives, Huong T. Pham, Adam J. Trevitt, Todd W. Mitchell, and Stephen J. Blanksby

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Stereoselective synthesis of α-methylenecyclopentenones via a Diels-Alder/retro-Diels-Alder protocol, Weerachai Phutdhawong, Gedsirin Eksinitkun, Stephen G. Pyne, Anthony C. Willis, and Waya S. Phutdhawong

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An evaluation of ferrihydrite- and Metsorb™-DGT techniques for measuring oxyanion species (As, Se, V, P): effective capacity, competition and diffusion coefficients, Helen L. Price, Peter R. Teasdale, and Dianne F. Jolley

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Human P2X7 receptor activation induces the rapid shedding of CXCL16, Aleta Pupovac, Christopher M. Foster, and Ronald Sluyter

Human P2X7 receptor activation induces ADAM10-mediated shedding of CD23 and CXCL16 (P4137), Aleta Pupovac, Bin Wang, Christopher Foster, and Ronald Sluyter