RIS ID

77363

Publication Details

Yue, Z., Moulton, S. E., Cook, M., O'Leary, S. & Wallace, G. G. (2013). Controlled delivery for neuro-bionic devices. Advanced Drug Delivery Reviews, 65 (4), 559-569.

Abstract

Implantable electrodes interface with the human body for a range of therapeutic as well as diagnostic applications. Here we provide an overview of controlled delivery strategies used in neuro-bionics. Controlled delivery of bioactive molecules has been used to minimise reactive cellular and tissue responses and/or promote nerve preservation and neurite outgrowth toward the implanted electrode. These effects are integral to establishing a chronically stable and effective electrode-neural communication. Drug-eluting bioactive coatings, organic conductive polymers, or integrated microfabricated drug delivery channels are strategies commonly used.

Grant Number

ARC/DP0987344

Share

COinS
 

Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.addr.2012.06.002