Title

Electrical stimulation promotes nerve cell differentiation on polypyrrole/poly(2-methoxy-5 aniline sulfonic acid) composites

RIS ID

30155

Publication Details

Liu, X., Gilmore, K. J., Wallace, G. G. & Moulton, S. E. (2009). Electrical stimulation promotes nerve cell differentiation on polypyrrole/poly(2-methoxy-5 aniline sulfonic acid) composites. Journal of Neural Engineering, 6 (6), 65002-65012.

Abstract

The purpose of this work was to investigate for the first time the potential biomedical applications of novel polypyrrole (PPy) composites incorporating a large polyelectrolyte dopant, poly (2-methoxy-5 aniline sulfonic acid) (PMAS). The physical and electrochemical properties were characterized. The PPy/PMAS composites were found to be smooth and hydrophilic and have low electrical impedance. We demonstrate that PPy/PMAS supports nerve cell (PC12) differentiation, and that clinically relevant 250 Hz biphasic current pulses delivered via PPy/PMAS films significantly promote nerve cell differentiation in the presence of nerve growth factor (NGF). The capacity of PPy/PMAS composites to support and enhance nerve cell differentiation via electrical stimulation renders them valuable for medical implants for neurological applications.

Grant Number

ARC/FF0669110

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Link to publisher version (DOI)

http://dx.doi.org/10.1088/1741-2560/6/6/065002