Title

Three-dimensional neuronal cell culture: in pursuit of novel treatments for neurodegenerative disease

RIS ID

116871

Publication Details

Carter, S. D., Liu, X., Yue, Z. & Wallace, G. (2017). Three-dimensional neuronal cell culture: in pursuit of novel treatments for neurodegenerative disease. MRS Communications, 7 (3), 320-331.

Abstract

To gain a better understanding of the underlying mechanisms of neurological disease, relevant tissue models are imperative. Over the years, this realization has fuelled the development of novel tools and platforms, which aim at capturing in vivo complexity. One example is the field of biofabrication, which focuses on fabrication of three-dimensional (3D) biologically functional products in a controlled and automated manner. Herein, we provide a general overview of classical 3D cell culture platforms, particularly in the context of neurodegenerative disease. Subsequently, the focus is put on bioprinting-based biofabrication, its potential to advance 3D neuronal cell culture and, to conclude, the relevant translational bottlenecks, which will need to be considered as the field evolves.

Grant Number

ARC/CE140100012

Grant Number

ARC/FL110100196

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