Title

Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

RIS ID

115241

Publication Details

Masud, M. Kamal., Islam, M., Haque, M. Hakimul., Tanaka, S., Gopalan, V., Alici, G., Nguyen, N., Lam, A. K., Hossain, M. Al., Yamauchi, Y. & Shiddiky, M. J. A.(2017). Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA. Chemical Communications, (58), 8231-8234.

Abstract

This paper reports the development of a nonenzymatic, amplificationfree, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).

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Link to publisher version (DOI)

http://dx.doi.org/10.1039/c7cc04789d