Title

Superparamagnetic gadolinium ferrite nanoparticles with controllable Curie temperature - cancer theranostics for MR-imaging-guided magneto-chemotherapy

RIS ID

109446

Publication Details

Thorat, N. D., Bohara, R. A., Tofail, S. A. M., Alothman, Z. Abdullah., Shiddiky, M. J. A., Hossain, M., Yamauchi, Y. & Wu, K. C.-W. (2016). Superparamagnetic gadolinium ferrite nanoparticles with controllable Curie temperature - cancer theranostics for MR-imaging-guided magneto-chemotherapy. European Journal of Inorganic Chemistry, 2016 (28), 4586-4597.

Abstract

A facile polyol approach for preparing low-Curie-temperature (TC) gadolinium-doped iron oxide nanoparticles (GdIO NPs) for targeted magnetic hyperthermia and chemotherapy coupled with T1-T2 dual-model magnetic resonance (MR) imaging (where T1 and T2 are the longitudinal and transverse relaxation times, respectively) is reported. A small amount of Gd doping decreases the TC of iron oxide down to about 400 K. In the presence of ethanolamine, controlled polyol synthesis leads to the formation of low-TC, highly magnetic (52.87 emu g-1), and size-controlled (ca. 10 nm) GdIO NPs. A further conjugation with folate and a chemotherapeutic drug has been developed, and the whole system is used for in vitro magneto-chemotherapy (magnetic hyperthermia and chemotherapy) for cancer treatment. The synthesized GdIO NPs are stable colloids that are hemocompatible and cytocompatible over a wide concentration range and have a high affinity towards cancer cells. The release of a chemotherapeutic drug from the GdIO NPs significantly affects cancer cell viability, and the T1-T2 dual-model magnetic resonance enhances bioimaging in a breast cancer cell model. We suggest that the chemotherapeutic-drug-conjugated GdIO NPs have great potential for cell targeting and magnetic resonance imaging in cancer magneto-chemotherapy.

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Link to publisher version (DOI)

http://dx.doi.org/10.1002/ejic.201600706