Using an electrical potential to reversibly switch surfaces between two states for dynamically controlling cell adhesion

Authors

Cheuk Chi Albert Ng, University of New South Wales
Astrid I. Magenau, University of New South Wales
Siti Hawa Ngalim, University of New South Wales
Simone Ciampi, University of New South WalesFollow
Muthukumar Chockalingham, University of New South Wales
Jason Brian Harper, University of New South Wales
Katharina Gaus, University of New South WalesFollow
J Justin Gooding, University of New South WalesFollow

RIS ID

105092

Publication Details

Ng, C., Magenau, A., Ngalim, S., Ciampi, S., Chockalingham, M., Harper, J. Brian., Gaus, K. & Gooding, J. Justin. (2012). Using an electrical potential to reversibly switch surfaces between two states for dynamically controlling cell adhesion. Angewandte Chemie - International Edition, 51 (31), 7706-7710.

Abstract

Smart surfaces presenting both antifouling molecules with a charged functional group at their distal end, and molecules that are terminated by RGD peptides for cell adhesion, were fabricated and characterized (see picture). By applying potentials of +300 or -300 mV, the surfaces could be dynamically switched to make the peptide accessible or inaccessible to cells.