RIS ID

104394

Publication Details

Mirabedini, A., Foroughi, J., Romeo, T. & Wallace, G. G. (2015). Development and characterization of novel hybrid hydrogel fibers. Macromolecular Materials and Engineering, 300 (12), 1217-1225.

Abstract

Biopolymeric continuous core-sheath fibres, with an inner core of chitosan and alginate as the sheath, were fabricated for the first time without using a template. Hereby, the necessary conditions to achieve chitosan-alginate core-sheath fibre via a wet-spinning process are presented. SEM micrographs show the cylinder-shaped monofilament structure of the chitosan core surrounded by the alginate sheath. The coaxial fibres exhibit a 260% increase in ultimate stress and more than 300% enhancement in the Young's modulus compared to the alginate counterpart. Release profiles from the coaxial fibre were determined using a model component. The obtained results suggest that the fibres are likely to find applications as 3D tissue scaffolds capable of drug delivery.

Grant Number

ARC/DE130100517, ARC/CE140100012, ARC/FL110100196

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Link to publisher version (DOI)

http://dx.doi.org/10.1002/mame.201500152