Title

Targeting and uptake of multilayered particles to colorectal cancer cells

RIS ID

101139

Publication Details

Cortez, C., Tomaskovic-Crook, E., Johnston, A. P. R., Radt, B., Cody, S. H., Scott, A. M., Nice, E. C., Heath, J. K. & Caruso, F. (2006). Targeting and uptake of multilayered particles to colorectal cancer cells. Advanced Materials, 18 (15), 1998-2003.

Abstract

Core/shell particles and capsules formed by a layer-by-layer technique are biofunctionalized with a humanized A33 monoclonal antibody (huA33 mAb) that binds to the A33 antigen present on colorectal cancer cells (see figure). Targeting to a colorectal cancer cell line shows selective binding and internalization of particles.

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Link to publisher version (DOI)

http://dx.doi.org/10.1002/adma.200600564