Title

The generation of GLP-grade human embryonic stem cell banks from four clinical-grade cell lines for preclinical research

RIS ID

92482

Publication Details

Sivarajah, S., Raj, G. Selva., Mathews, A. Varughese., Sahib, N. Binte Esmail., Hwang, W. Sek. & Crook, J. Micah. (2010). The generation of GLP-grade human embryonic stem cell banks from four clinical-grade cell lines for preclinical research. In Vitro Cellular and Developmental Biology: Animal, 46 (3-4), 210-216.

Abstract

The Singapore Stem Cell Bank has generated human embryonic stem cell banks from clinical-grade cell lines ESI-017, ESI-035, ESI-049, and ESI-053. All banks were prepared and characterized according to principles of Good Laboratory Practice for quality assurance. Importantly, each cell line has clearly documented and approved ethical provenance and meets recognized standards for performance and safety. The banks are intended to facilitate the translation of stem cell research to clinical medicine by enabling early phase research and development with high-quality, low-cost cells that are also available as clinical-grade stocks.

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Link to publisher version (DOI)

http://dx.doi.org/10.1007/s11626-010-9287-1